Fluocinoloni acetonidum
Fluocinolone Acetonide
CAS: 67-73-2
Molecular Formula: C24H30F2O6
Fluocinoloni acetonidum - Names and Identifiers
Fluocinoloni acetonidum - Physico-chemical Properties
| Molecular Formula | C24H30F2O6 |
| Molar Mass | 452.49 |
| Density | 1.1826 (estimate) |
| Melting Point | 267-269°C(lit.) |
| Boling Point | 578.5±50.0 °C(Predicted) |
| Specific Rotation(α) | D +95° (chloroform) |
| Flash Point | 303.7°C |
| Water Solubility | Soluble in water (partly), DMSO, alcohol, chloroform and methanol. |
| Solubility | DMSO 90 mg/mL ;Water <1 mg/mL; Ethanol 12 mg/mL. Insoluble in water, easily soluble in acetone, dissolved in ethanol and chloroform, slightly soluble in ether. |
| Vapor Presure | 8.57E-16mmHg at 25°C |
| Appearance | White Solid |
| Color | White to Off-White |
| Merck | 14,4150 |
| pKa | 12.78±0.70(Predicted) |
| Storage Condition | Refrigerator |
| Refractive Index | 103 ° (C=1, MeOH) |
| MDL | MFCD00010525 |
| Physical and Chemical Properties | White or off-white crystalline powder, odorless, tasteless. [Α] D20 80- 88 ° (dioxane). Soluble in acetone, slightly soluble in ethanol, dioxane, insoluble in water, petroleum ether. From 11 α-hydroxy -16 α,17 α-epoxypregnane -4-ene -3,20-Dione by sulfonation, ring opening and other 16 step reaction. For allergic dermatitis, contact dermatitis, eczema and other skin diseases. |
| Use | Suitable for the treatment of eczema, neurodermatitis, skin pruritus, contact dermatitis, psoriasis, solar dermatitis and other diseases |
Fluocinoloni acetonidum - Risk and Safety
| Risk Codes | R36/37/38 - Irritating to eyes, respiratory system and skin. R40 - Limited evidence of a carcinogenic effect R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S22 - Do not breathe dust. |
| WGK Germany | 3 |
| RTECS | TU3830000 |
| HS Code | 2937220000 |
| Toxicity | LD50 oral in rat: > 4gm/kg |
Fluocinoloni acetonidum - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| corticosteroids | acetic acid skin easy also known as fluoride easy, fluceonide, flumetian, xiannaile, acetonated fluorine Xinlong, is currently the most significant effect of topical corticosteroids in China and a less side effect, can make the dermal capillary contraction, inhibition of connective tissue cell proliferation or regeneration; Can also stabilize the intracellular lysosomal membrane, prevent intracellular lysosomal enzymes release histamine and cause tissue damage. Its anti-inflammatory effect is 100 times of hydrocortisone, the use of the lowest concentration (0.025%) that has obvious effect, and effective quickly, can significantly reduce or heal within a few days, antipruritic effect is better. Acetic acid skin is mainly used for skin diseases that are effective against glucocorticoids, such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, neurodermatitis, solar dermatitis, eczema (especially infantile eczema), skin pruritus, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, etc. Compatibility with antibiotics such as neomycin can treat purulent skin diseases. With 0.025-0.05% ointment, lotion applied to wipe the net of the affected area, 2-3 times a day, can be gently knead to promote its penetration into the skin. |
| pharmacological action | fluocinonate acetate is a fluorine-containing glucocorticoid. 0.01% external preparation for the medium effect, 0.025% external preparation for the strong glucocorticoid. Can make the dermal capillary contraction, inhibit epidermal cell proliferation or regeneration, inhibit connective tissue proliferation, stable intracellular lysosomal membrane, reduce inflammatory exudation, it can inhibit the formation and release of histamine and other inflammatory mediators, and has anti-allergic, anti-inflammatory and antipruritic effects. |
| indications | for contact dermatitis, allergic dermatitis, seborrheic dermatitis, neurodermatitis, solar dermatitis, eczema, psoriasis, lichen planus and cutaneous pruritus. |
| fluoroacetic acid | fluoroacetic acid is a synthetic, fluorine-containing, potent steroid. External use can make the dermal capillary contraction, inhibit the proliferation or regeneration of epidermal cells, inhibit the neogenesis of fiber cells in the connective tissue, stabilize the intracellular lysosomal membrane, and has anti-inflammatory and antipruritic effects. After external application, it can be absorbed through intact skin. After absorption and systemic administration of corticosteroids in the body metabolism, mainly in the liver metabolism, through the kidney. Fluoride acetate is easily applied to skin diseases effective for corticosteroids, such as eczema (especially infantile eczema), neurodermatitis, pruritus, contact dermatitis, psoriasis, discoid lupus erythematosus, lichen planus, otitis externa, solar dermatitis, etc. But need to pay attention to long-term or large-area use can cause skin atrophy, telangiectasia, the occurrence of acne-like dermatitis, perioral dermatitis, folliculitis, increase susceptibility to infection. Occasionally may cause allergic contact dermatitis. |
| adverse reactions | long-term or large-scale application, especially blocking therapy can cause systemic adverse reactions due to absorption, clinical symptoms include Cushing's syndrome, hyperglycemia, glycosuria, etc. Long-term or large-area application can also cause skin atrophy, telangiectasia, acne-like dermatitis, perioral dermatitis, folliculitis and can induce skin infections and aggravate infectious skin diseases. |
| precautions | ① for topical preparations of potent glucocorticoids, long-term and large-area application is not allowed. (2) applied to the face and skin folds, should carefully weigh the pros and cons. ③If accompanied by skin infection, anti-infective drugs must be used at the same time. If the symptoms of infection do not improve in time after simultaneous use, the product should be discontinued until the infection is controlled. (4) pregnant women and lactating women should weigh the pros and cons with caution. Pregnant women can not be long-term, large or heavy use. It should not be applied to eyes. The children and infants due to the relatively large body surface area, should weigh the pros and cons should be used with caution, should minimize the amount of drugs, and can not be used packet treatment. |
| biological activity | Fluocinolone acetate (Flucort-N) is a corticosteroid that binds to the cytoplasmic glucocorticoid receptor. |
| Target | Value |
| Use | for allergic dermatitis, contact dermatitis, seborrheic dermatitis, eczema, etc. suitable for the treatment of eczema, neurodermatitis, skin pruritus, contact dermatitis, psoriasis, solar dermatitis and other diseases |
| toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |
Last Update：2024-04-09 15:16:52
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